Results: Median follow-up time was 58.2 months.
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The median and mean durations of implant were 100.0 hours and 101.1 hours (range, 71-165 hours). The median and average total doses were 63.0 Gy and 62.5 Gy (range, 56-69 Gy), respectively. The median and average dose rates at the tumor apex were 63.5 cGy/h and 62.7 cGy/h, respectively. COMS eye plaques were used with dose prescribed to the apex of the tumor. Methods and Materials: From 1990 to 2004, 62 patients were treated with iodine- 125 plaque brachytherapy for choroidal melanoma. This is a retrospective review of our outcomes in patients treated with lower doses than those used in the COMS. In the COMS, the prescription dose was 85 Gy.
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Purpose: The Collaborative Ocular Melanoma Study (COMS) established iodine- 125 plaque brachytherapy as an accepted standard treatment for medium-size choroidal melanoma. Programa de Pos-graduacao em Ciencias e Tecnicas NuclearesĪlternative Dose for Choroidal Melanoma Treated With an Iodine- 125 Radioactive Plaque: A Single-Institution Retrospective Study Nucleo de Engenharia Hospitalar Campos, Tarcisio [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). [Centro Federal de Educacao Tecnologica (CEFET/MG), Belo Horizonte, MG (Brazil). Programa de Pos-graduacao em Ciencias e Tecnicas Nuclearesĭosimetry on ocular brachytherapy with ROPE plaque with iodine25 and palladium-103 Dosimetria em braquiterapia ocular com placa ROPES contando sementes de iodo- 125 e paladio-103 [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Advantages include: simple construction from inexpensive components, customized shape, and iodine seeds that are readily visible on plane radiographsĭosimetry on ocular brachytherapy with ROPES plaque with Iodine- 125 and Palladium-103 seeds Dosimetria em braquiterapia ocular com placa ROPES contendo sementes de iodo- 125 e paladium-103Įnergy Technology Data Exchange (ETDEWEB) Completed plaques consist of a back wall, a 2-mm side wall, and a 1.5-mm wide lip with holes for suture placement.
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Using a simple manual mechanism, the two forms are stamped over a customized acrylic die shaped to the dimensions of the tumor base plus a 2-mm margin. Each plaque is formed from two flat circular gold/palladium foils which are used in dental crown work. The authors have developed a new inexpensive precious metal alloy plaque for use in customized iodine- 125 plaque therapy. (author)Ī new inexpensive customized plaque for choroidal melanoma iodine- 125 plaque therapy The present model represents an advance in simulating and predicting absorbed dose on ocular brachytherapy. The maximum dose is found onto the eyeball, in the vitreous. The results are normalized to 100% at the maximum dose on the tumor base, and by the applied source activity. The computational simulation allows evaluating how the dose rates are spatially distributed in the orbital volume. Simulations are performed on the MCNP5 code. Thus, a three-dimensional computational model of ocular area was developed to simulate orbital irradiation with ROPES ophthalmologic plaque placed on the sclera surface filled to ten iodine- 125 seeds, and palladium-103 seeds. Brachytherapy instead of teletherapy looks for departuring absorbed doses in tumor minimizing doses in the lens and the adjacent tissues of the eyeball (orbital region), avoiding deleterious effects. However, the irradiation of ocular region can bring deleterious effects due to the high doses, mainly in the lens, retina and in the bone structures in growth phase. Radiotherapy is an alternative to ocular enucleation. (author)ĭosimetry on ocular brachytherapy with ROPES plaque with Iodine- 125 and Palladium-103 seeds
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Brachytherapy instead of teletherapy looks for departing absorbed doses in tumor minimizing doses in the lens and the adjacent tissues of the eyeball (orbital region), avoiding deleterious effects. International Nuclear Information System (INIS) Dosimetry on ocular brachytherapy with ROPE plaque with iodine 125 and palladium-103